What is the difference between leprosy and psoriasis

Skin biopsy of the trunk demonstrated psoriasiform dermatitis with negative Fite stains Figure 6. The patient was started on minocycline, rifampin, and dapsone for his leprosy, oral prednisone for his neuritis, and light therapy for his psoriasis. Coexistence of psoriasis and leprosy is rare in the published literature. A survey of , cases of leprosy found only 20 individuals with psoriasis. One proposed hypothesis is that resisting leprosy may have been the evolutionary advantage that favored the expansion of psoriasis-associated genotypes.

Lepromatous leprosy is characterized by a predominant Type 2 helper T-cell Th2 immune response and failure to build granulomas in lesions, whereas tuberculoid leprosy is characterized by a Th1 immune response and granulomatous inflammation. Psoriasis is characterized by a genetic predisposition to strong Th1 immune polarization that may evolutionarily keep M. This has led to the hypothesis that psoriasis may protect against the clinical progression of leprosy and that leprosy may have been historically contained because of the increased prevalence of psoriasis.

Nerve involvement in leprosy leads to destruction of cutaneous nerve fibers and absence of neuropeptides such as substance P, which may play a functional role in psoriatic proliferation. Damage to sensory nerves has been reported to clear psoriatic lesions, leading to the hypothesis that it may be the leprosy-associated neuropathy that results in inhibiting the psoriatic disease process.

The patient is of Norwegian ancestry, which was the last European country with the highest concentration of endemic leprosy. Louis, MO, E-mail: umar. Powered by: PubFactory. Sign in Sign up. Members Institutions Cost.

Advanced Search Help. Export Figures View in gallery Erythematous plaques with overlying silvery scales on the abdomen, elbows, and knees bilaterally. View in gallery Annular patches with scales can be seen on the upper and lower back. View in gallery Closer view of both type of lesions: erythematous plaques with overlying silvery scales and large annular patches.

View in gallery High-power Fite stain of the left peroneal nerve revealing a large number of acid-fast bacilli within the histiocytes and Schwann cells in the nerve fascicles. View in gallery Punch biopsy from a psoriatic lesion on the abdomen consistent with psoriasis. Close View raw image Erythematous plaques with overlying silvery scales on the abdomen, elbows, and knees bilaterally.

View raw image Annular patches with scales can be seen on the upper and lower back. Eczema and psoriasis are like twins — they have a similar look, but deep down, they are fundamentally different. Both eczema and psoriasis can cause a rash — patches of red, raised, itchy skin — and they can appear in the same places of the body, such as the hands and scalp.

Neither is contagious but both can lead to infections. Although eczema can be more prevalent in the United States, psoriasis is also common. This makes self-diagnosis even harder, because the chance for getting either condition is high.

However, despite the confusingly similar appearances, there are clues that can help you tell them apart. Psoriasis is an autoimmune disease , meaning your immune system is dysfunctional and your skin cells grow too fast.

The cause of eczema is much more complicated and hard to determine. Both genetic and environmental factors could play a role in triggering the rash. Researchers have found in some eczema patients that a gene responsible for creating a protective layer on the top of the skin has mutated changed , which leaves the skin prone to infection and flare.

Some interesting disease combinations - Report on two cases. Lepr India ; Leprosy and the natural selection for psoriasis. Med Hypotheses ; Aberrant expression of apoptosis-related molecules in psoriatic epidermis. J Dermatol Sci ; Apoptosis in leprosy patients. This article has been cited by 1 Psoriasis y lepra, pasado y presente Eduardo Fonseca Capdevila Piel. Year : Volume : 7 Issue : 1 Page : If you have leprosy and experience numbness or a loss of sensation in the affected body region, contact your doctor to discuss ways to prevent injury.

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