Treximet how does it work

How well did Treximet work for you? Did you experience many side effects while taking this drug? How likely would you be to recommend Treximet to a friend? Back Submit. Uses of Treximet Back to Top. Manufacturer Back to Top. Pernix Therapeutics, LLC. Generic Back to Top. Sumatriptan and Naproxen For more information on this medication choose from the list of selections below. Brand Name Drug Class. Treximet Drug Class Back to Top. Treximet is part of the drug class: Selective serotonin.

Side Effects of Treximet Back to Top. Serious side effects have been reported with Treximet. Common side effects of Treximet include the following: dizziness tiredness burning or prickling feeling in the hands, arms, legs, or feet paresthesia nausea stomach upset dry mouth chest discomfort pain in the neck, throat, or jaw This is not a complete list of Treximet side effects.

Tell your doctor if you have any side effects that bother you or that do not go away. Treximet Interactions Back to Top. Treximet Precautions Back to Top. Serious side effects have been reported with Treximet including the following: Heart attack or stroke: Tell your healthcare provider right away if you have some or all of the following symptoms: shortness of breath chest pain weakness slurring of speech New hypertension or worsening of preexisting hypertension: Have your blood pressure watched by your doctor closely if taking Treximet, especially if you have a history of hypertension or are taking medications to treat hypertension.

Call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome: mental changes such as seeing things that are not there hallucinations , agitation, or coma fast heartbeat changes in blood pressure high body temperature tight muscles trouble walking nausea, vomiting, or diarrhea Liver toxicity: Tell your healthcare provider right away if you have some or all of the following symptoms: flu-like symptoms itchiness fatigue nausea yellow tinting of the skin or eyes Kidney injury: Patients at greatest risk of this are those who already have renal dysfunction, heart failure, liver injury, those taking diuretics or ACE inhibitors, and the elderly.

Anaphylactoid reaction: Tell your healthcare provider right away if you have some or all of the following symptoms: swelling of the face or throat or trouble swallowing difficulty breathing, coughing, chest tightness, wheezing dizziness, fainting, rapid or weak heartbeat flushing, itching, hives or a feeling of warmth Pregnancy: In late pregnancy, Treximet should be avoided since one of the ingredients naproxen may cause premature closure of the ductus arteriosus.

Pre-existing asthma: Treximet should not be taken in patients with aspirin-sensitive asthma and should be used with caution in patients with preexisting asthma. Anemia: Tell your healthcare provider right away if you have some or all of the following symptoms: Shortness of breath Dizziness Headache Coldness in the hands and feet Pale skin Chest pain Treximet can cause dizziness or drowsiness.

Do not take Treximet if you have a history of: a hypersensitivity allergic reaction to Treximet asthma, hives, or other allergic-type reactions after taking NSAIDs including naproxen, one of the two active ingredients in Treximet other aspirin coronary artery bypass graft CABG surgery; naproxen is not to be used for treating pain before or after this surgery heart problems or a history of heart problems narrowing of blood vessels to your legs, arms, stomach, or kidney peripheral vascular disease uncontrolled high blood pressure severe liver problems hemiplegic migraines or basilar migraines.

If you are not sure if you have these types of migraines, ask your healthcare provider. Treximet and other medicines may affect each other, causing side effects. If there is no response to the first migraine attack treated with Treximet, a physician should reconsider the migraine diagnosis prior to using the medication in any subsequent attacks. A cardiovascular evaluation should be performed on patients who have never taken a triptan medication but who have multiple cardiovascular risk factors e.

For those with a cardiac history, the first dose of Treximet should be administered in a medically supervised setting and an electrocardiogram ECG should be performed immediately following the dose. Because Treximet can cause dizziness, weakness, or drowsiness, you should not not drive a car, use machinery, or do anything requiring you to be fully alert when taking this medication. Keep track of when you have migraine attacks and when you take Treximet so you can monitor its effectiveness and communicate with your doctor about how the medication is working for you.

You should begin no medication or supplement without first checking with your health care provider and should let them know of any other prescriptions, OTCs, and herbals you are taking to ensure there are no interactions. For additional details, read the full prescribing information of Treximet. By providing your email address, you are agreeing to our privacy policy.

We never sell or share your email address. All rights reserved. Always consult your doctor about your medical conditions. Peripheral or GI vascular ischemia and infarction following other 5-HT 1 agonists.

Hypertension; monitor BP closely. Hepatic impairment. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic, and renal function in long-term therapy. Pre-existing asthma. Seizure disorders. May mask signs of infection or fever. Discontinue at 1 st sign of rash or any other hypersensitivity. May be associated with a reversible delay in ovulation in females of reproductive potential. Nursing mothers: minimize infant exposure by avoiding breastfeeding for 12hrs after dose.

See Contraindications. Treximet tm , is approved by the Food and Drug Administration. The purpose of this research study is to compare the effectiveness of taking Treximet tm as a combination pill to taking two Aleve r tablets and mg of Imitrex r as separate tablets taken at the same time. Three tablets taken concurrently with migraine onset. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.

For general information, Learn About Clinical Studies. A subject will be eligible for inclusion in this study if all of the following criteria apply:. A subject will not be eligible for inclusion in this study if any of the following criteria apply:. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

Search for terms. Save this study. Warning You have reached the maximum number of saved studies Migraine Treatment Satisfaction With Treximet Versus Concomitant 2 Aleve and Imitrex The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Last Update Posted : October 13, Study Description. This is an open label, 6 month cross over study in 50 migraine patients fulfilling International Headache Society Classification criteria for migraine headache with and without aura having migraines per month and not over 14 days a month of headaches in the previous 3 months.

Baseline Headache Impact Test -6 HIT-6 will be obtained and 25 patients will administer Treximet as needed for 3 months and then 2 Aleve and mg Imitrex taken concomitantly as needed for 3 months.

The other 25 patients will administer 2 Aleve and mg Imitrex taken concomitantly as needed for 3 months and then Treximet as needed for 3 months. In addition to Revised Patient Perception of Migraine Questionnaire PPMQ-R data, a detailed diary will be recorded regarding number of tablets taken per attack, compliance, rescue treatment, when patients treated their migraine attack mild, moderate, or severe , onset of pain reduction pain relief and pain free, and 24 hour pain relief and sustained pain free response.

Detailed Description:.